Study on correlation between midtrimester HbA1c with OGTT for the screening of Gestational Diabetes Mellitus

Abstract

The present study, a prospective observational study was carried out in department of Obstetrics and Gynaecology at Dr. KNS Memorial Institute of Medical Sciences Gadia, Barabanki .With the aim to study the correlation between midtrimester HbA1c and OGTT for the diagnosis of gestational diabetes mellitus .We included 120 patients in the study group in which HbA1c and OGTT was measured between 24 to 28 weeks of gestation. In our study out of 120 patients 22 patients had GDM on the basis of OGTT (WHO 1999). The OGTT fasting values indicate that out of 120 participants, 108 (90%) had fasting glucose levels ≤125 mg/dl, while 12 (10%) had levels ≥126 mg/dl. For the OGTT 2nd-hour values, 98 participants (81.7%) had glucose levels ≤139 mg/dl, whereas 22 participants (18.3%) had levels ≥140 mg/dl. the GDM positive group had a higher proportion of participants with HbA1c values of 6.1 or higher
(36.4%) compared to the GDM negative group (0%). The mean HbA1c values were 5.95 for the GDM positive group and 5.32 for the GDM negative group. The HbA1c distribution difference between the two groups was statistically significant